预约演示

更新于：2025-05-07

Infarction, Anterior Cerebral Artery

大脑前动脉脑梗死

更新于：2025-05-07

基本信息

别名

ACA Infarct、ACA Infarction、ACA Infarctions

+ [37]

简介

NECROSIS occurring in the ANTERIOR CEREBRAL ARTERY system, including branches such as Heubner's artery. These arteries supply blood to the medial and superior parts of the CEREBRAL HEMISPHERE, Infarction in the anterior cerebral artery usually results in sensory and motor impairment in the lower body.

关联

靶点-

作用机制

细胞替代物

在研机构-

原研机构

Post Graduate Institute of Medical Education & Research

在研适应症-

非在研适应症

急性缺血性卒中 [+3]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

项与大脑前动脉脑梗死相关的临床试验

ChiCTR2500099924

/ Suspended临床3期IIT

Recanalization and Acute Perfusion Improvement through Intra-arterial Delivery of Methylprednisolone

开始日期2025-05-01

申办/合作机构-

CTRI/2025/04/084323

/ Not yet recruiting临床2期IIT

Effect of a Home-based Gamified, Intensive, and Functional Tele-rehabilitation (Home-GIFT) program on improving upper limb function following stroke - NIL

开始日期2025-04-15

申办/合作机构-

NCT06702657

/ Not yet recruitingN/AIIT

A Randomized Clinical Trial on Urgent Angioplasty for IntraCranial Atherosclerotic Stenosis-related Large-Vessel Occlusion After Mechanical Thrombectomy (ICAS LVO-MT)

A prospective, multicenter, randomized controlled, open-label, blinded outcome evaluation (PROBE) trial

开始日期2025-03-15

申办/合作机构

海军军医大学第一附属医院

[+1]

100 项与大脑前动脉脑梗死相关的临床结果

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100 项与大脑前动脉脑梗死相关的转化医学

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0 项与大脑前动脉脑梗死相关的专利（医药）

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1,298

项与大脑前动脉脑梗死相关的文献（医药）

2025-05-13·Neurology

Influence of Asymptomatic Hemorrhagic Transformation After Endovascular Treatment on Stroke Outcome

Article

作者: Fernández-Vidal, Joan Miquel ; Martínez-González, Jose Pablo ; Camps-Renom, Pol ; Guasch-Jiménez, Marina ; Rodríguez Vázquez, Alejandro ; Lambea-Gil, Álvaro ; Seró, Laia ; Purroy, Francisco ; Xuclà-Ferrarons, Tomas ; Ezcurra Díaz, Garbiñe ; Martinez-Domeño, Alejandro ; Abilleira, Sònia ; Fernandez-Cadenas, Israel ; Cánovas, David ; Ramos-Pachón, Anna ; Prats-Sanchez, Luis ; Rodriguez-Campello, Ana ; Toscano-Prat, Clara ; Rodriguez-Villatoro, Noelia ; Cardona, Pere ; Gomis, Meritxell ; Salvat-Plana, Mercè ; Marti-Fabregas, Joan

BACKGROUND AND OBJECTIVESIn patients with acute ischemic stroke (AIS), the impact of hemorrhagic transformation (HT) after endovascular treatment (EVT) on poorer stroke outcome is well established when associated with clinical deterioration. However, the influence of asymptomatic HT remains unclear. We aimed to examine the impact of asymptomatic HT after EVT on functional outcome and mortality.METHODSDrawing on Catalan (Spain) population-based prospective stroke registry data, we included patients from 10 comprehensive stroke centers with anterior circulation AIS (2017-2023) who underwent EVT, excluding patients without data on the presence of HT or functional outcome at 3 months of follow-up. HT was categorized as parenchymal hemorrhage (PH), hemorrhagic infarct (HI) types 1 and 2, and remote PH (rPH). Asymptomatic HT was defined as any HT not causing death or the NIH Stroke Scale (NIHSS) score to increase by ≥ 4 points. Functional outcome was centrally assessed using the modified Rankin Scale (mRS). The primary end point was a shift in the 3-month mRS score. After excluding symptomatic intracerebral hemorrhage (sICH), multivariable ordinal regression analyses (adjusted by age, mRS, baseline NIHSS score, baseline Alberta Stroke Program Early CT Score, and modified Thrombolysis In Cerebral Infarction score ≥2b) were performed to test for asymptomatic HT association with the primary end point.RESULTSWe included 3,067 patients (72.0 ± 13.6 years, 50.7% women), 179 (5.8%) with sICH and 612 (20.0%) with asymptomatic HT. HT category frequencies were 8.9% HI1, 7.2% HI2, 4.4% PH1, 3.8% PH2, and 1.5% rPH. The percentage of asymptomatic patients showed a hierarchical distribution, ranging from 93.4% in HI1 to 25.0% in PH2. In the multivariable analysis, asymptomatic HT was associated with poorer outcomes (common odds ratio [cOR] 2.24, 95% CI 1.89-2.66) and higher mortality (adjusted odds ratio 1.50, 95% CI 1.17-1.91). In the sensitivity analyses, the association with functional outcome remained significant for each HT category, with asymptomatic PH2 showing the highest odds of poorer outcomes (cOR 3.15, 95% CI 1.46-6.83).DISCUSSIONIn patients with AIS undergoing EVT, asymptomatic HT was associated with poorer functional outcomes and higher mortality, suggesting that any HT, regardless of its clinical impact or radiologic category, should be considered as an additional EVT safety measure.

2025-05-01·World Neurosurgery

Analysis of Prognostic Risk Factors in Patients with Complete Revascularization After Thrombectomy for Acute Anterior Circulation Large Vessel Occlusion

Article

作者: Wang, Xuewen ; Xie, Zhitao ; Li, Zhuoben ; Wu, Haike ; Jiang, Chen ; Zhuang, Chenqi ; Yang, Qingjiang ; Ha, Xiaojun ; Chen, Wenlin ; Zhu, Qiang ; Wu, Zhixin ; Gong, Lifen ; Zhang, Xueying

OBJECTIVEPrognostic risk factors were analyzed for patients with acute anterior circulation large vessel occlusion stroke who achieved modified Treatment in Cerebral Ischemia (mTICI) 3 grade by endovascular treatment.METHODSPatients with Acute ischemic stroke with mTICI=3 grade after endovascular treatment from June 2019 to September 2024, at the Eighth Clinical College of Guangzhou University of Traditional Chinese Medicine, were retrospectively analyzed. Data related to patients' baseline data, risk factors, test data, and surgical data were collected, and the primary endpoint was 90-day poor functional outcome, defined as patients' modified Rankin score >2 at 90 days after surgery. The predictive effect was evaluated using receiver operating characteristic curve analysis, and multivariate logistic regression analysis was used to explore the independent correlation between inflammatory markers and prognosis.RESULTSA total of 103 eligible patients were included. Multivariate logistic regression analysis showed that the neutrophil-to-lymphocyte ratio (NLR) (odds ratio [OR] = 1.10, 95% confidence interval [CI]: 1.01∼1.20, P = 0.021) at 24 hours after surgery, 7-day National Institute of Health stroke scale (NIHSS) score: (OR = 1.15, 95% CI: 1.07∼1.23, P < 0.001), diabetes history: (OR = 9.60, 95% CI: 2.41∼38.26, P = 0.001), was independently associated with poor prognosis in patients with mTICI = grade 3 after endovascular therapy. Receiver operating characteristic curve analysis: NLR (area under the curve [AUC] = 0.687, 95% CI: 0.584∼0.790) at 24 hours after surgery, NIHSS (AUC = 0.826, 95% CI: 0.746∼0.906), and diabetes history (AUC = 0.667, 95% CI: 0.563∼0.771). Three-marker combined predictive indicators (AUC = 0.889, 95%CI: 0.829∼0.949) CONCLUSIONS: In patients with acute anterior large vascular occlusive stroke with mTICI = grade 3 after endovascular therapy, NIHSS score at 7 days after surgery, NLR within 24 hours after surgery, and history of diabetes were independent influencing factors for poor prognosis. Patients with a history of diabetes who had a NLR ≥6.7 within 24 hours and a NIHSS score ≥4.5 at 7 days after surgery were more likely to have a poor prognosis.

2025-05-01·Behavioural Brain Research

White matter tract involvement in anarchic hand syndrome following stroke: Diffusion tensor imaging study

Article

作者: Park, Jihee ; Lee, Sekwang ; Tae, Woo-Suk ; Pyun, Sung-Bom

Anarchic Hand Syndrome (AHS) is a rare neurological disorder characterized by involuntary, purposeful hand movements. AHS can also result from damage to the corpus callosum (CC), intra-hemispheric tracts, or descending tracts, but its precise causes remain unclear. This study aimed to identify the white matter tracts associated with AHS development using the automated reconstruction of 42 tracts from diffusion tensor imaging (DTI). We included three female AHS patients with anterior cerebral arterial (ACA) infarctions. Additionally, we enrolled 20 age-matched control subjects and six patients with ACA infarctions but without AHS symptoms (N-AHS group) for comparison. DTI was conducted in AHS, N-AHS, and control groups. Fractional anisotropy (FA) and volume values were extracted from the DTI datasets of participants using TRActs Constrained by UnderLying Anatomy (TRACULA) technique. The AHS group showed lower FA values of the CC body (parietal and temporal section), right arcuate fasciculus (AF), corticospinal tract, extreme capsule, inferior longitudinal fasciculus (ILF), and superior longitudinal fasciculus than the control group. However, these tracts exhibited no significant difference between N-AHS and control groups. Similarly, the volume value in the genu of CC in the AHS group was lower than controls, but not in other tracts. Our results suggests that the extensive CC lesion, especially in the posterior parietal and temporal section of CC body, and damage to intra-hemispheric tracts (AF and ILF), is associated with the development of AHS. These results involved in AHS and underscore the significance of considering a more complex network disruption, involving various white matter tracts beyond CC for understanding this syndrome.