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更新于：2026-07-06
Guangzhou Wondfo Biotech Co., Ltd.
更新于：2026-07-06
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NCT04207554
Clinical Investigation for the Preview® hCG Urine/Serum Combo Pregnancy Test
NCT03907449
Preview Rapid Strep A Test Method Comparison Study
100 项与 广州万孚生物技术股份有限公司 相关的临床结果
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2026-01-01COLLOIDS AND SURFACES B-BIOINTERFACES
Surface-engineered MnO₂@Au@ZIF-67 hierarchical catalysts for acid-triggered antibacterial therapy and infected wound healing
Article
作者: Wang, Yan ; Wang, LinGe ; Yu, Xiaolin ; Dong, Xuehui ; Yu, Qianqian ; Gao, Li ; Tang, Zhe ; Yang, Bo ; Xu, Mengmeng ; Liu, Yuan
Rational surface engineering of nanocatalysts offers new solutions against antibiotic-resistant infections. We designed and fabricated hierarchical MnO₂@Au@ZIF-67 nanoparticles (NPs) with triple interfacial functionalities for synergistic antibacterial therapy. The acid-responsive ZIF-67 surface degrades in infected wounds, releasing Co²⁺ to catalyze •OH generation via Fenton-like reactions at the material-bacteria interface. Simultaneously, ultrasmall Au surfaces deplete glucose through oxidase-mimetic catalysis, producing gluconic acid that accelerates ZIF-67 dissolution. The MnO₂ core surface decomposes H₂O₂ to supply O₂, enhancing Au catalysis and alleviating hypoxia. Comprehensive surface characterization (TEM, SEM, XPS, XRD) confirmed structural integrity and reactive sites. In vitro, the NPs achieved > 99 % bacterial killing (S. aureus/E. coli) through ROS-mediated membrane disruption (validated by SEM/CLSM). In vivo, they enabled 98.45 % bacterial clearance and accelerated wound healing via collagen reorganization (H&E/Masson staining). This surface-engineered platform demonstrates how interfacial catalytic cascades can be harnessed for effective non-antibiotic antimicrobial applications.
2022-07-01Biosensors & bioelectronics1区 · 工程技术
Argonaute-integrated isothermal amplification for rapid, portable, multiplex detection of SARS-CoV-2 and influenza viruses
1区 · 工程技术
Article
作者: Li, Zhonglei ; Liu, Qian ; Wang, Hanming ; Feng, Yan ; Liu, Tao ; Li, Kai ; Sun, Junwei ; Zhao, Pengshu ; Wang, Li ; Xu, Sihong ; Zhao, Weili ; Huang, Jun ; Guo, Xiang ; Wang, Jihua ; Zhou, Haiwei ; Liu, Donglai ; Xu, Heshan ; Ye, Xingyu
Isothermal amplification methods are a promising trend in virus detection because of their superiority in rapidity and sensitivity. However, the generation of false positives and limited multiplexity are major bottlenecks that must be addressed. In this study, we developed a multiplex Argonaute (Ago)-based nucleic acid detection system (MULAN) that integrates rapid isothermal amplification with the multiplex inclusiveness of a single Ago for simultaneous detection of multiple targets such as SARS-CoV-2 and influenza viruses. Owing to its high specificity, MULAN can distinguish targets at a single-base resolution for mutant genotyping. Moreover, MULAN also supports portable and visible devices with a limit of detection of five copies per reaction. Validated by SARS-CoV-2 pseudoviruses and clinical samples of influenza viruses, MULAN showed 100% agreement with quantitative reverse-transcription PCR. These results demonstrated that MULAN has great potential to facilitate reliable, easy, and quick point-of-care diagnosis for promoting the control of infectious diseases.
2021-12-01CHINESE CHEMICAL LETTERS
The point-of-care-testing of nucleic acids by chip, cartridge and paper sensors
作者: Zuozhong Wu ; Yuan Guo ; Song Li ; Zhu Chen ; Lei Cai ; Yan Deng ; Xiaoni Zhao ; Nongyue He ; Jinqu Yan ; Tao Wang ; Yuyue Xu ; Lian Jin
A review.Point-of-care nucleic acid testing (POCNAT) has played an important role in the outbreak of infectious diseases (e.g., COVID-19) over recent years.POCNAT aims to realize the rapid, simple, and automatic detection of nucleic acid.Thanks to the development of manufacturing technol., electronic information technol., artificial intelligence technol., and biol. information technol. in recent years, the development of the POCNAT device has led to significant advancement.Instead of the normal nucleic acid detection methods used in the laboratory, some novel exptl. carriers have been applied, such as chips, cartridges, and papers.The application of these exptl. carriers has realized the automation and integration of nucleic acid detection.The entire process of nucleic acid detection is normally divided into 3 steps (nucleic acid extraction, target amplification, and signal detection).All of the reagents required by the process can be pre-stored on these exptl. carriers, without unnecessary manual operation.Furthermore, all of the processes are carried out in this exptl. carrier, with the assistance of a specific control device.Although they are complicated to manufacture and precise in design, their application provides a significant step forwards in nucleic acid detection and realizes the integration of nucleic acid detection.This technol. has great potential in the field of point-of-care mol. diagnostics in the future.This paper focuses on the relevant content of these exptl. carriers.
100 项与 广州万孚生物技术股份有限公司 相关的药物交易
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100 项与 广州万孚生物技术股份有限公司 相关的转化医学
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