PRR7

更新于：2025-05-07

基本信息

别名

MGC10772、proline rich 7, synaptic、Proline-rich protein 7

+ [2]

简介

Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222).

关联

100 项与 PRR7 相关的临床结果

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100 项与 PRR7 相关的转化医学

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0 项与 PRR7 相关的专利（医药）

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项与 PRR7 相关的文献（医药）

2024-11-01·New Phytologist

HOS15‐mediated turnover of PRR7 enhances freezing tolerance

Article

作者: Kim, Yeon Jeong ; Kim, Woe‐Yeon ; Somers, David E.

Summary

Arabidopsis PSEUDORESPONSE REGULATOR7 (PRR7) is a core component of the circadian oscillator which also plays a crucial role in freezing tolerance. PRR7 undergoes proteasome‐dependent degradation to discretely phase maximal expression in early evening. While its repressive activity on downstream genes is integral to cold regulation, the mechanism of the conditional regulation of the PRR7 abundance is unknown.

We used mutant analysis, protein interaction and ubiquitylation assays to establish that the ubiquitin ligase adaptor, HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 15 (HOS15), controls the protein accumulation pattern of PRR7 through direct protein–protein interactions at low temperatures. Freezing tolerance and electrolyte leakage assays show that PRR7 enhances cold temperature sensitivity, supported by ChIP‐qPCR at C‐REPEAT BINDING FACTOR1 (CBF1) and COLD‐REGULATED 15A (COR15A) promoters where PRR7 levels were higher in hos15 mutants.

HOS15 mediates PRR7 turnover through enhanced ubiquitylation at low temperature in the dark. Under the same conditions, increased PRR7 association with the promoters of CBFs and COR15A in hos15 correlates with decreased CBF1 and COR15A transcription and enhanced freezing sensitivity.

We propose a novel mechanism whereby HOS15‐mediated degradation of PRR7 provides an intersection between the circadian system and other cold acclimation pathways that lead to increased freezing tolerance.

2024-05-14·Plant And Cell Physiology

Correction To: Root PRR7 Improves the Accuracy of the Shoot Circadian Clock through Nutrient Transport

作者: Araki, Takashi ; Mori, Fumito ; Endo, Motomu ; Takahashi, Nozomu ; Uemoto, Kyohei ; Kubota, Akane ; Egashira, Haruki ; Kunimoto, Yumi ; Takemiya, Atsushi ; Ito, Hiroshi ; Yamauchi, Shota

2024-04-01·Planta

Unlocking allelic variation in circadian clock genes to develop environmentally robust and productive crops

Review

作者: Spillane, Charles ; Dwivedi, Sangam Lal ; Wu, Rongling ; Quiroz, Luis Felipe ; Ortiz, Rodomiro ; Mattoo, Autar K

AbstractMain conclusionMolecular mechanisms of biological rhythms provide opportunities to harness functional allelic diversity in core (and trait- or stress-responsive) oscillator networks to develop more climate-resilient and productive germplasm.AbstractThe circadian clock senses light and temperature in day–night cycles to drive biological rhythms. The clock integrates endogenous signals and exogenous stimuli to coordinate diverse physiological processes. Advances in high-throughput non-invasive assays, use of forward- and inverse-genetic approaches, and powerful algorithms are allowing quantitation of variation and detection of genes associated with circadian dynamics. Circadian rhythms and phytohormone pathways in response to endogenous and exogenous cues have been well documented the model plant Arabidopsis. Novel allelic variation associated with circadian rhythms facilitates adaptation and range expansion, and may provide additional opportunity to tailor climate-resilient crops. The circadian phase and period can determine adaptation to environments, while the robustness in the circadian amplitude can enhance resilience to environmental changes. Circadian rhythms in plants are tightly controlled by multiple and interlocked transcriptional–translational feedback loops involving morning (CCA1, LHY), mid-day (PRR9, PRR7, PRR5), and evening (TOC1, ELF3, ELF4, LUX) genes that maintain the plant circadian clock ticking. Significant progress has been made to unravel the functions of circadian rhythms and clock genes that regulate traits, via interaction with phytohormones and trait-responsive genes, in diverse crops. Altered circadian rhythms and clock genes may contribute to hybrid vigor as shown in Arabidopsis, maize, and rice. Modifying circadian rhythms via transgenesis or genome-editing may provide additional opportunities to develop crops with better buffering capacity to environmental stresses. Models that involve clock gene‒phytohormone‒trait interactions can provide novel insights to orchestrate circadian rhythms and modulate clock genes to facilitate breeding of all season crops.

项与 PRR7 相关的新闻（医药）

2023-06-30

·生物谷

科研人员揭示新的植物生物钟周期精细调控因子

生物钟作为植物细胞内在计时机制，通过协调基因表达的节律性和代谢稳态等，使植物更好地适应地球自转和公转引起的昼夜性和季节性环境变化。当植物内源生物钟系统和外界光-暗周期相一致时，植物会获得最佳生长，因此生物钟作为植物细胞内在计时机制，通过协调基因表达的节律性和代谢稳态等，使植物更好地适应地球自转和公转引起的昼夜性和季节性环境变化。当植物内源生物钟系统和外界光-暗周期相一致时，植物会获得最佳生长，因此，维持较为稳定的生物钟周期对植物生长发育至关重要。近期，中国科学院植物研究所王雷团队发现一类进化上相对保守的B-box类蛋白，其中第五亚家族成员BBX28和BBX29参与生物钟周期的精细调控。超表达BBX28或BBX29以及它们的功能缺失突变会影响生物钟周期。该团队通过蛋白互作筛选发现，BBX28和BBX29可以与生物钟中央振荡器核心组分PRR9、PRR7和PRR5蛋白在细胞核内直接互作，并能增强PRRs蛋白对靶基因的转录抑制活性。转录组分析发现，BBX28和BBX29主要抑制转录峰值在早晨的基因表达，且二者在基因表达调控上存在功能冗余，其中BBX28起主要作用。RNA-Seq和ChIP-seq数据联合分析发现，BBX28/BBX29与PRRs在生物钟基因调控中处于同一通路，协同调控早晨表达的生物钟基因。此外，研究发现BBX28和BBX29的转录水平也受到PRRs蛋白的反馈调控，这进一步增强了生物钟的稳定性。该研究发现了新的生物钟调控因子BBX28和BBX29，并揭示了这些调控因子通过与生物钟核心组分PRRs互作，精细调控生物钟周期的机制。BBX28和BBX29是进化上较为保守的BBXs蛋白。该研究或为其他作物如水稻，大豆等的生物钟调控机制提供借鉴意义。相关研究成果在线发表在《植物、细胞与环境》（Plant, Cell & Environment）上。研究工作得到中国科学院战略性先导科技专项（B类）和国家自然科学基金的支持。

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