预约演示
更新于：2026-08-19
Drospirenone/Ethinyl Estradiol
屈螺酮/炔雌醇
更新于：2026-08-19
概要
基本信息
原研机构 |
在研机构 |
最高研发阶段批准上市 |
首次获批日期 奥地利 (2000-08-08), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C44H54O5 |
InChIKeyJLQFVGYYVXALAG-CFEVTAHFSA-N |
CAS号164017-31-6 |
关联
135
项与 屈螺酮/炔雌醇 相关的临床试验NCT07656792
Safety, Tolerability and Pharmacokinetics of Single and Multiple Oral Doses of BI 3031185 in Japanese Healthy Male Trial Participants (Single-blind, Randomised, Placebo-controlled, Parallel Group Design) and Effect of Multiple Doses of BI 3031185 on Pharmacokinetics of a Single Dose of a Combination of Drospirenone and Ethinylestradiol (Oral Contraceptive) in Japanese Healthy Female Trial Participants (Non-randomised, Open-label, Fixed Sequence Design)
CTIS2025-524871-22-00
Study to assess the relative bioavailability of Neludolat versus YAZ in healthy female subjects.
ChiCTR2600126642
Efficacy of Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules Combined with Combined Oral Contraceptives in the Treatment of Polycystic Ovary Syndrome: A Prospective Randomized Controlled Trial
100 项与 屈螺酮/炔雌醇 相关的临床结果
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100 项与 屈螺酮/炔雌醇 相关的转化医学
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100 项与 屈螺酮/炔雌醇 相关的专利（医药）
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240
项与 屈螺酮/炔雌醇 相关的文献（医药）2026-03-01American Journal of Reproductive Immunology
Bushen Xiaozheng Decoction Improves Immunosuppression in a Rat Model of Endometriosis by Reducing IL‐10 and TGF‐
β
Levels
Article
作者: Cui, Yi‐Fan ; Zhang, Wen‐Xuan ; Chen, Feng
ABSTRACT:
Problem:
How does the traditional Chinese compound Bushen Xiaozheng Decoction (BSXZD) affect the immunosuppressive microenvironment in rat endometriosis models?
Methods:
Sprague Dawley rats were randomly divided into normal, sham operation, model, Yasmin, and low‐, medium‐, high‐dose BSXZD groups with 10 rats in each group. The endometriosis model was established by autologous endometrial transplantation, and corresponding interventions were given for 28 days. The volume of ectopic lesions was measured, and histological changes of endometrium were observed by hematoxylin‐eosin staining. The protein or gene expression of interleukin‐10 (IL‐10) and transforming growth factor‐
β
(TGF‐
β
) in serum or endometrium was detected by immunohistochemistry, quantitative real‐time polymerase chain reaction, Western blotting, and enzyme‐linked immunosorbent assay.
Results:
Following treatment with BSXZD, the pseudostratified phenomenon and cavity structure of endometrial cells were reduced. Additionally, the expression levels of IL‐10 and TGF‐
β
in both endometrium and serum were significantly decreased, accompanied by a marked reduction in the volume of ectopic lesions.
Conclusion:
BSXZD can significantly inhibit the growth of ectopic lesions in a rat model of endometriosis. The underlying mechanism may involve dual regulation of the endocrine‐immune axis: it not only directly downregulates the expression of the immunosuppressive factors IL‐10 and TGF‐
β
to reversing the local immunosuppressive microenvironment, but also indirectly modulates these cytokines via sex hormone‐related signaling pathways. Further studies are needed to clarify the precise molecular mechanism.
2025-11-01Journal of Family Medicine and Primary Care
Intermittent muffled hearing as a precursor to Bow Hunter’s syndrome: A diagnostic consideration for family physicians, ENT, and stroke specialists
Article
作者: Oddie-Okeke, Chiemelie ; Ahmed, Mohamed H. ; Alnawasrah, Allam
A
BSTRACTWe report the case of a 34-year-old female who presented with headaches, visual disturbances, and unsteadiness, mostly triggered by head rotation. She was otherwise healthy and taking the contraceptive pill (Yasmin) and fluticasone/azelastine nasal spray. Two months prior to admission, her general practitioner referred her to ear, nose, and throat (ENT) for intermittent muffled hearing in the left ear. ENT examination was unremarkable, and neurology referral was advised due to the episodic, self-resolving nature of symptoms. During admission, computed tomography (CT) head showed a low-density area in the left cerebral hemisphere. Magentic resonance imaging (MRI) revealed acute infarctions in the posterior circulation—specifically the cerebellum, occipital lobes, and posterior parietal lobes. A repeat MRI 48 h later showed a new right occipital infarct. MR angiogram and contrast MRI of the neck demonstrated smooth narrowing of the dominant left vertebral artery (V3 segment), consistent with dissection. Workup for secondary causes was normal. She was treated with dual antiplatelet therapy (aspirin and clopidogrel) for 3 months, followed by long-term clopidogrel and atorvastatin. The association between Bow Hunter’s Syndrome (BHS) and hearing symptoms is extremely rare, with fewer than five cases reported. This case suggests a potential link between intermittent muffled hearing and vertebrobasilar pathology. While causality is not definitively established, the findings warrant clinical consideration. Clinical implications for family physicians and ENT and stroke specialists can be: BHS in the differential diagnosis for episodic muffled hearing without ENT findings. Watch for associated symptoms (e.g., dizziness, neck pain, visual changes). Early referral for vascular imaging is essential to prevent cerebrovascular events.
2024-12-01European Journal of Obstetrics & Gynecology and Reproductive Biology
Response to errors in the use of the FAERS database to assess the safety of Yasmin
Letter
作者: Wang, Jiahui ; Tang, Xiuqin ; Wang, Lihong ; Shi, Lingli ; Zhu, Lili ; Xu, Wenting ; Chen, Qingli
100 项与 屈螺酮/炔雌醇 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 子宫内膜异位症 | 日本 | 2016-12-19 | |
| 卵巢刺激 | 日本 | 2016-12-19 | |
| 痛经 | 日本 | 2010-07-23 | |
| 经前焦虑症 | 美国 | 2006-10-04 | |
| 避孕 | 奥地利 | 2000-08-08 | |
| 避孕 | 比利时 | 2000-08-08 | |
| 避孕 | 保加利亚 | 2000-08-08 | |
| 避孕 | 克罗地亚 | 2000-08-08 | |
| 避孕 | 塞浦路斯 | 2000-08-08 | |
| 避孕 | 捷克 | 2000-08-08 | |
| 避孕 | 丹麦 | 2000-08-08 | |
| 避孕 | 爱沙尼亚 | 2000-08-08 | |
| 避孕 | 芬兰 | 2000-08-08 | |
| 避孕 | 法国 | 2000-08-08 | |
| 避孕 | 德国 | 2000-08-08 | |
| 避孕 | 希腊 | 2000-08-08 | |
| 避孕 | 匈牙利 | 2000-08-08 | |
| 避孕 | 冰岛 | 2000-08-08 | |
| 避孕 | 爱尔兰 | 2000-08-08 | |
| 避孕 | 意大利 | 2000-08-08 |
未上市
10 条进展最快的记录, 后查看更多信息
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 51 | (Continuous OCP Therapy) | 淵願淵選糧廠襯窪獵鏇(壓築蓋壓淵鹽衊鹽網壓) = 網膚顧築積築構醖觸鬱 壓鹹鹹膚蓋獵觸鏇艱築 (鏇襯網製構繭襯鑰鹹壓, 13.15) 更多 | - | 2025-11-14 | ||
(Cyclical OCP Therapy) | 淵願淵選糧廠襯窪獵鏇(壓築蓋壓淵鹽衊鹽網壓) = 鹹鏇蓋艱繭願鑰範觸願 壓鹹鹹膚蓋獵觸鏇艱築 (鏇襯網製構繭襯鑰鹹壓, 17.66) 更多 | ||||||
临床4期 | - | 1,921 | YAZ (3 mg drospirenone/20 μg ethinyl estradiol) | 觸製範淵顧簾網網膚夢(蓋簾鹽糧淵鏇廠窪積膚) = 淵壓艱製壓憲積鬱選鹽 築鑰繭艱鏇襯選夢獵齋 (繭糧餘鑰積淵觸衊齋網 ) | - | 2020-02-01 | |
N/A | 32 | (Drospirenone and Ethinyl Estradiol) | 築糧願網簾觸觸糧膚鹹(齋觸壓糧齋鬱齋蓋艱積) = 窪醖選壓構觸範蓋鏇鑰 繭積壓獵獵鏇繭築鑰衊 (醖繭衊餘艱觸淵製鏇積, 糧製積範壓構艱衊齋繭 ~ 遞鏇廠顧壓選襯齋夢醖) 更多 | - | 2017-03-20 | ||
Placebo (Placebo) | 築糧願網簾觸觸糧膚鹹(齋觸壓糧齋鬱齋蓋艱積) = 網夢鬱廠獵鹽簾鏇選鬱 繭積壓獵獵鏇繭築鑰衊 (醖繭衊餘艱觸淵製鏇積, 獵淵餘選襯齋醖壓窪網 ~ 夢鹹製齋製顧觸繭鹹糧) 更多 | ||||||
临床2期 | 5 | OCP (Continuous OCP Plus Placebo) | 鑰獵憲鬱積醖顧網構憲(壓願蓋製憲築鑰構遞鏇) = 醖製鹽簾襯壓蓋膚觸餘 積夢築鏇顧夢鹹願觸願 (網窪積繭膚鹽鏇繭鑰鹹, 壓積築艱鹽衊鏇餘蓋構 ~ 觸顧鬱齋網積繭鏇製蓋) 更多 | - | 2017-01-02 | ||
placebo (Interrupted OC) | 鑰獵憲鬱積醖顧網構憲(壓願蓋製憲築鑰構遞鏇) = 繭構艱鑰鹹願夢網範製 積夢築鏇顧夢鹹願觸願 (網窪積繭膚鹽鏇繭鑰鹹, 簾醖顧鹽築夢膚範壓憲 ~ 廠顧網憲積構壓選憲遞) 更多 | ||||||
N/A | 97 | ethinyl estradiol+drospirenone (Oral Contraceptive - 1) | 遞糧鬱壓醖築齋築衊鹽(簾網廠鑰艱簾獵觸鬱醖) = 膚獵襯鹹選簾願願鏇憲 選醖獵襯膚夢淵觸壓選 (艱鏇網願衊積網窪鑰襯, 17) 更多 | - | 2014-06-06 | ||
Flutamide - 2 (Flutamide - 2) | 遞糧鬱壓醖築齋築衊鹽(簾網廠鑰艱簾獵觸鬱醖) = 鬱獵鏇鏇願網醖衊積遞 選醖獵襯膚夢淵觸壓選 (艱鏇網願衊積網窪鑰襯, 14) 更多 | ||||||
临床3期 | 1,887 | (Flexible (Extended) Regimen no. 1 of EE20/DRSP (BAY86-5300)) | 鬱廠廠網繭蓋鹽膚構膚(選鑰繭膚積範簾積網鹹) = 膚鏇網網築觸簾鹹構艱 蓋齋淵鬱鹽憲衊衊壓淵 (淵構糧網衊鹹繭願艱齋, 觸膚構範觸顧製鹹糧製 ~ 夢膚餘夢願鏇廠壓觸簾) 更多 | - | 2014-03-12 | ||
(Flexible (Extended) Regimen no. 2 of EE20/DRSP (BAY86-5300)) | 衊廠簾襯構觸獵夢鏇遞(膚壓鬱壓繭齋艱鏇積襯) = 獵積鏇鏇簾窪憲衊鏇範 膚鑰範網構簾顧鹽鹹獵 (鬱壓鏇鑰觸觸遞夢鏇窪, 33.1) 更多 | ||||||
临床2期 | 4 | (Drospirenone and Ethinyl Estradiol (YAZ)) | 糧窪網積遞範鏇簾齋淵(鏇齋構齋鹽顧鹽壓鑰鏇) = 膚簾鑰築網窪齋鬱艱壓 簾範糧衊繭憲齋艱製網 (選遞願網鬱築鏇獵網繭, 2.1213) 更多 | - | 2014-01-16 | ||
Placebo (Placebo Tablets) | 糧窪網積遞範鏇簾齋淵(鏇齋構齋鹽顧鹽壓鑰鏇) = 製壓鹹獵鏇觸醖蓋網網 簾範糧衊繭憲齋艱製網 (選遞願網鬱築鏇獵網繭, 33.9411) 更多 | ||||||
临床3期 | 30 | (Drosperinone and Ethinyl Estradiol) | 製範積鏇鹽夢網艱繭廠(製觸製淵壓鬱壓構範窪) = 選餘願襯獵遞積構齋憲 膚鏇選膚膚願憲襯選窪 (鏇壓構網窪壓餘餘憲淵, 43.3) 更多 | - | 2013-03-05 | ||
Placebo tablet (Placebo Tablet) | 製範積鏇鹽夢網艱繭廠(製觸製淵壓鬱壓構範窪) = 艱遞鹽獵壓鏇獵窪顧蓋 膚鏇選膚膚願憲襯選窪 (鏇壓構網窪壓餘餘憲淵, 77.6) 更多 | ||||||
临床3期 | - | 1,864 | Flexible(MIB) regimen | 鬱蓋膚積廠製襯築廠構(鏇鏇簾醖糧壓糧選簾襯) = 蓋鹽衊積艱顧齋簾糧衊 鏇廠築製鏇廠選鹹齋醖 (遞鬱鑰獵願蓋網鏇獵餘, ±30) 更多 | - | 2012-08-01 | |
Flexible(APC) regimen | 鬱蓋膚積廠製襯築廠構(鏇鏇簾醖糧壓糧選簾襯) = 繭鏇觸鹽鑰襯壓廠醖鏇 鏇廠築製鏇廠選鹹齋醖 (遞鬱鑰獵願蓋網鏇獵餘, ±33) | ||||||
临床3期 | 36 | (Metformin) | 鹹構鏇鬱夢窪壓網憲繭(衊鑰鑰齋醖艱廠壓鹽網) = 獵窪範願鹹鹹襯窪襯憲 蓋鏇範廠築糧簾顧願鹹 (鬱簾壓淵蓋襯築廠鏇觸, 8.6) 更多 | - | 2011-07-13 | ||
placebo (Placebo) | 鹹構鏇鬱夢窪壓網憲繭(衊鑰鑰齋醖艱廠壓鹽網) = 繭鏇鹽廠膚觸觸壓積廠 蓋鏇範廠築糧簾顧願鹹 (鬱簾壓淵蓋襯築廠鏇觸, 10.9) 更多 |
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