预约演示
更新于：2026-08-20
Alovudine
阿洛夫定
更新于：2026-08-20
概要
基本信息
原研机构 |
权益机构- |
最高研发阶段临床前 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C10H13FN2O4 |
InChIKeyUXCAQJAQSWSNPQ-XLPZGREQSA-N |
CAS号25526-93-6 |
关联
21
项与 阿洛夫定 相关的临床试验NCT03633955
Multi-institutional Prospective Pilot Study of Radiology Evaluation of Acute Leukemia Infiltration analyZed by Experimental Imaging
JPRN-UMIN000041491
The influence of stem cell source on dynamics of hematopoiesis and allogeneic hematopoietic cell transplantation outcome evaluated by 18F-FLT PET/MRI
JPRN-UMIN000029524
study on [F-18] FDG and [F-18] FLT in the assessment of malignant tumors
100 项与 阿洛夫定 相关的临床结果
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100 项与 阿洛夫定 相关的转化医学
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100 项与 阿洛夫定 相关的专利（医药）
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516
项与 阿洛夫定 相关的文献（医药）2026-01-16JOURNAL OF PHYSICS-CONDENSED MATTER
Self-oscillations induced by self-induced torque in magnetic double tunnel junction
Article
作者: Arun, R ; Gopal, R ; Lakshmanan, M ; Chandrasekar, V K
Abstract:
Self-oscillations of the magnetization due to self-induced torque (SIT) in a magnetic double tunnel junction that consists of perpendicularly polarized, pinned and free layers is investigated along with the field-like torque (FLT). The associated Landau–Lifshitz–Gilbert–Slonczewski equation is numerically analyzed to exhibit the oscillations of magnetization driven by the current. From the numerical analysis, we show that the SIT is essential to generate oscillations in the order of GHz and without it the magnetization reaches steady state after exhibiting switching. Without FLT, the frequency of the oscillations decreases with the current while the power of oscillations increases. In the presence of the negative strength of the FLT the power spectral density confirms that the frequency, power and the Q-factor increase with the current. Also the tunability range and the rate at which the frequency enhances increase with the magnitude of the FLT.
2025-12-01INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
Decreasing differences in first-line therapy for respiratory infections in urgent cares, results of a multi-institutional quality improvement collaborative
Article
作者: Kronman, Matthew P ; Sainz, Luis E. ; El Feghaly, Rana E. ; Lee, Brian R. ; Hamdy, Rana F. ; Nedved, Amanda ; Parente, Victoria ; Hersh, Adam L.
Abstract:
Objective::
We aimed to decrease the difference in first-line therapy (ΔFLT) for common acute respiratory infections (ARI) in pediatric urgent care clinics (PUCs) in relation to race, ethnicity, language, and insurance using quality improvement (QI) methodology.
Design::
Retrospective cohort study of 13-month pre-intervention (April 2022–April 2023) and 17-month (May 2023–September 2024) intervention data collection.
Setting::
92 PUC sites from 9 organizations spanning 22 states.
Patients::
Encounters of patients 6 months to 18 years of age with ARI diagnoses.
Methods::
Sites created local multidisciplinary QI teams, cause-and-effect analyses, driver diagrams, and used Plan-Do-Study-Act (PDSA) cycles. We defined FLT per national guidelines. We measured ΔFLT between socioeconomic groups as our primary outcome. Balancing measure was overall rate of FLT. Logistic regression models evaluated the impact education-only PDSAs had on ΔFLT compared to PDSAs that used education plus another intervention modality (eg clinical decision support).
Results::
We included 895,604 encounters. Despite our QI efforts, we saw no change in ΔFLT between Spanish and English-speaking patients (3.1%), Hispanic and non-Hispanic patients (1.6%), or commercial and government-insured patients (1.6%). We saw an increase in ΔFLT between Black and White patients from 3.6% to 5.8%. We observed fluctuations in overall rates of FLT over time. The impact of PDSA cycle types was variable.
Conclusions::
Despite local interventions to reduce differences in prescribing, we noted a widening of the ΔFLT by race. More work is needed to understand causes of these disparities and develop effective interventions that improve equitable antibiotic prescribing.
2025-11-01ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Inhalation bioaccessibility of polycyclic aromatic hydrocarbons from reference combustion-derived particles: Methodological aspects and toxicological impact on bronchial epithelial cells
Article
作者: Votier, Edwige ; Rogez-Florent, Tiphaine ; Monteil, Christelle ; Boutamba Mbina, Albana ; Bouzar, Clémence ; Yon, Jérôme
Combustion-derived particles are a significant concern due to their nanometric sizes and complex chemical compositions, which can negatively impact health. These particles contain polycyclic aromatic hydrocarbons (PAH) and their oxygenated derivatives (OPAH), which can dissolve in biological lung fluids. As a result, they form complex mixtures whose toxicity is often poorly studied. Therefore, evaluating inhalation bioaccessibility is crucial for accurately assessing the health risks associated with these particles. We determined the inhalation bioaccessibility fractions (IBAF) of 16 PAH and 5 OPAH from particles generated under controlled conditions. Several critical parameters were evaluated, including simulated lung fluids (SLF), extraction times, and solid-to-liquid (S/L) ratios. Our results indicated that eight compounds - NAP, ACY, FLU, 9-FLUO, PHE, ANT, FLT, PYR - were systematically extracted by the different SLF, namely Gamble's solution (GS), artificial lysosomal fluid (ALF), modified GS (MGS), and simulated epithelial lung fluid (SELF) after 24 h of extraction time with an S/L ratio of 1/2000. The evaluation of the toxicological response, based on cytotoxicity and the AhR-dependent pathway, demonstrated variability in the toxicological profiles, depending on the extraction conditions used. Notably, the extraction condition yielding a biological response equivalent to that assessed with the total particulate fraction was the use of MGS as the extraction fluid under our experimental conditions. From a toxicological perspective, these approaches appear relevant for assessing the toxicity mechanisms of PAH mixtures, closely mimicking the in vivo conditions found in the human respiratory tract. This study outlined that understanding whether the bioaccessible fraction of particulate-bound PAHs is a reliable predictor of toxicity is central to advancing inhalation risk assessment.
9
项与 阿洛夫定 相关的新闻（医药）2025-09-09
2025-09-01
放射疗法申请上市上市批准优先审批
2025-08-29
100 项与 阿洛夫定 相关的药物交易
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研发状态
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| HIV感染 | 临床2期 | - | 2004-04-01 | |
| 获得性免疫缺陷综合征 | 临床阶段不明 | 美国 | 2001-08-31 | |
| 艾滋病相关复合征 | 临床阶段不明 | 美国 | 2001-08-31 | |
| 急性髓性白血病 | 临床前 | 加拿大 | 2017-12-07 | |
| 急性髓性白血病 | 临床前 | 瑞典 | 2017-12-07 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 3 | 18F-thymidine (FLT) (18F-thymidine (FLT) PET/CT) | 壓艱鏇築網夢觸膚廠壓(鏇鬱鏇艱憲鬱糧鏇遞壓) = 鹽鹹鹽醖鬱築蓋網壓選 願遞製選壓餘鬱願製襯 (願觸鹽憲淵獵範夢憲糧, 3) | - | 2021-05-12 | ||
18F-thymidine+FLT (Baseline 18F-thymidine PET/CT (FLT-PET/CT)) | 遞鹽觸願範選壓遞願醖(構憲鬱鹹築淵遞憲構繭) = 積製齋衊膚夢選衊壓築 衊醖鑰膚網膚窪窪鬱艱 (齋鏇獵選範鑰鑰鹽壓糧, 積網鬱餘廠鑰積構繭選 ~ 網壓蓋鏇築網淵繭鑰廠) 更多 | ||||||
N/A | - | 15 | 築淵餘餘築鬱繭選選鹹(鏇構淵襯餘簾願積膚構) = 壓構範積蓋襯襯顧艱淵 壓鏇鏇鹹觸積鏇鬱餘範 (繭齋鏇顧鬱壓糧膚鹹繭 ) | - | 2002-01-01 |
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